Incipient Parallel Evolution of SARS-CoV-2 Deltacron Variant in South Brazil.

With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated. This study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil. We demonstrate that the recombination breakpoint is at the beginning of the Spike gene. The 5' genome portion (circa 22 kb) resembles the AY.101 (Delta), and the 3' genome portion (circa 8 kb nucleotides) is most similar to the BA.1.1 (Omicron). Furthermore, evolutionary genomic analyses indicate that the new strain emerged after a single recombination event between lineages of diverse geographical locations in December 2021 in South Brazil. This Deltacron, AYBA-RS, is one of the dozens of recombinants described in 2022. The submission of only four sequences in the GISAID database suggests that this lineage had a minor epidemiological impact. However, the recent emergence of this and other Deltacron recombinant lineages (XD, XF, and XS) suggests that gene flow and recombination may play an increasingly important role in the COVID-19 pandemic. We explain the evolutionary and population genetic theory that supports this assertion, concluding that this stresses the need for continued genomic surveillance. This monitoring is vital for countries where multiple variants are present, as well as for countries that receive significant inbound international travel.

Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction.

We aimed to describe the SARS-CoV-2 lineages circulating early pandemic among samples with S gene dropout and characterize the receptor-binding domain (RBD) of viral spike protein. Adults and children older than 2 months with signs and symptoms of COVID-19 were prospectively enrolled from May to October in Porto Alegre, Brazil. All participants performed RT-PCR assay, and samples with S gene dropout and cycle threshold < 30 were submitted to high-throughput sequencing (HTS). 484 out of 1,557 participants tested positive for SARS-CoV-2. The S gene dropout was detected in 7.4% (36/484) and a peak was observed in August. The B.1.1.28, B.1.91 and B.1.1.33 lineages were circulating in early pandemic. The RBD novel mutation (Y380Q) was found in one sample occurring simultaneously with C379W and V395A, and the B.1.91 lineage in the spike protein. The Y380Q and C379W may interfere with the binding of neutralizing antibodies (CR3022, EY6A, H014, S304).

Children Have Similar Reverse Transcription Polymerase Chain Reaction Cycle Threshold for Severe Acute Respiratory Syndrome Coronavirus 2 in Comparison With Adults.

BACKGROUND: The viral dynamics and the role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not completely understood. Our aim was to evaluate reverse transcription polymerase chain reaction (RT-PCR) cycle threshold (Ct) values among children with confirmed SARS-CoV-2 compared with that of adult subjects. METHODS: Patients (from 2 months to ≤18 years of age and adults) with signs and symptoms of acute SARS-CoV-2 infection for less than 7 days were prospectively enrolled in the study from May to November 2020. All participants performed RT-PCR assay for SARS-CoV-2 detection; Ct values of ORF1ab, N and S gene targets and the average of all the 3 probes were used as surrogates of viral load. RESULTS: There were 21 infants (2 months to <2 years), 40 children (≥2 to <12 years), 22 adolescents (≥12 to <18 years) and 293 adults of 376 participants with confirmed SARS-CoV-2 infections. RT-PCR Ct values from all participants less than 18 years of age, as well as from all childhood subgroups, were not significantly different from adults, comparing ORF1ab, N, S and all the gene targets together (P = 0.453). CONCLUSIONS: Ct values for children were comparable with that of adults. Although viral load is not the only determinant of SARS-CoV-2 transmission, children may play a role in the spread of coronavirus disease 2019 in the community.

Impacto psicológico del aislamiento por COVID-19 en jóvenes de San Carlos de Bariloche, Argentina: la mirada de los padres / Psychological impact of COVID-19 lockdown in children and adolescents from San Carlos de Bariloche, Argentina: Parents' perspective

Introducción. Los jóvenes no fueron muy afectados desde el punto de vista infeccioso por la pandemia de COVID-19. Sin embargo, las medidas de aislamiento social modificaron de manera profunda su estilo de vida, y se cree que esto los afecta psicológicamente. El objetivo fue evaluar el impacto del aislamiento por COVID-19en la salud emocional de jóvenes en escolaridad primaria o secundaria.Población y métodos. Participaron del estudio padres de jóvenes de San Carlos de Bariloche. Se evaluó la percepción del adulto sobre el impacto emocional y de comportamiento del aislamiento sobre el joven, cambio de hábitos de sueño, uso de pantallas, actividades deportivas y alimentación y de asistencia a consulta médica.Resultados. Se incluyeron 267 padres. El 96,3 % observó cambios emocionales y de comportamiento. Los más frecuentes fueron que estaban más aburridos (el 76,8 %), irritables (el 59,2 %), desganados (el 56,9 %) y enojados (el 54,7 %). Se observó que se levantaban y acostaban más tarde y dormían 30 minutos más. Además, el uso de pantallas por esparcimiento aumentó 3 horas durante los días hábiles. El tiempo dedicado a la actividad física no varió, pero sí cambió el tipo de actividades: la natación y los deportes de equipo fueron reemplazados por ciclismo, caminatas y esquí.Conclusiones. El aislamiento por COVID-19impactó sobre la salud emocional y los hábitos de los jóvenes. El aburrimiento, la irritabilidad y el desgano estuvieron más presentes durante el aislamiento. La posibilidad de realizar actividades al aire libre permitió que continuaran practicando deportes.

Introduction. From an infectious perspective, children and adolescents were not highly affected by the COVID-19 pandemic. However, social isolation measures have deeply changed their lifestyle, which is believed to have a psychological impact on them. The objective was to assess the impact of COVID-19 lockdown on the emotional health of children and adolescents attending primary or secondary school.Population and methods. Parents of children and adolescents from San Carlos de Bariloche participated in the study. Adults' perception of the emotional and behavioral impact of lockdown on children and adolescents, changes in sleeping habits, screen use, sports-related activities, eating, and medical consultations, was assessed.Results. A total of 267 parents were included. Of them, 96.3 % noticed emotional and behavioral changes. The most common ones were that their children were more bored (76.8 %), more irritable (59.2 %), more reluctant (56.9 %), and angrier (54.7 %). It was observed that they woke up and went to bed later, and slept 30 minutes more. Moreover, leisure screen use increased by 3 hours on weekdays. Time dedicated to physical activities did not change, but the type of activities did: swimming and team sports were replaced by biking, walking, and skiing.Conclusions. COVID-19 lockdown affected the emotional health and habits of children and adolescents. Boredom, irritability, and reluctance were more present during lockdown. The possibility of doing outdoor physical activities allowed them to keep practicing sports

Psychological impact of COVID-19 lockdown in children and adolescents from San Carlos de Bariloche, Argentina: Parents' perspective. / Impacto psicológico del aislamiento por COVID-19 en jóvenes de San Carlos de Bariloche, Argentina: la mirada de los padres.

INTRODUCTION: From an infectious perspective, children and adolescents were not highly affected by the COVID-19 pandemic. However, social isolation measures have deeply changed their lifestyle, which is believed to have a psychological impact on them. The objective was to assess the impact of COVID-19 lockdown on the emotional health of children and adolescents attending primary or secondary school. POPULATION AND METHODS: Parents of children and adolescents from San Carlos de Bariloche participated in the study. Adults' perception of the emotional and behavioral impact of lockdown on children and adolescents, changes in sleeping habits, screen use, sports-related activities, eating, and medical consultations, was assessed. RESULTS: A total of 267 parents were included. Of them, 96.3 % noticed emotional and behavioral changes. The most common ones were that their children were more bored (76.8 %), more irritable (59.2 %), more reluctant (56.9 %), and angrier (54.7 %). It was observed that they woke up and went to bed later, and slept 30 minutes more. Moreover, leisure screen use increased by 3 hours on weekdays. Time dedicated to physical activities did not change, but the type of activities did: swimming and team sports were replaced by biking, walking, and skiing. CONCLUSIONS: COVID-19 lockdown affected the emotional health and habits of children and adolescents. Boredom, irritability, and reluctance were more present during lockdown. The possibility of doing outdoor physical activities allowed them to keep practicing sports.

Introducción. Los jóvenes no fueron muy afectados desde el punto de vista infeccioso por la pandemia de COVID-19. Sin embargo, las medidas de aislamiento social modificaron de manera profunda su estilo de vida, y se cree que esto los afecta psicológicamente. El objetivo fue evaluar el impacto del aislamiento por COVID-19 en la salud emocional de jóvenes en escolaridad primaria o secundaria. Población y métodos. Participaron del estudio padres de jóvenes de San Carlos de Bariloche. Se evaluó la percepción del adulto sobre el impacto emocional y de comportamiento del aislamiento sobre el joven, cambio de hábitos de sueño, uso de pantallas, actividades deportivas y alimentación y de asistencia a consulta médica. Resultados. Se incluyeron 267 padres. El 96,3 % observó cambios emocionales y de comportamiento. Los más frecuentes fueron que estaban más aburridos (el 76,8 %), irritables (el 59,2 %), desganados (el 56,9 %) y enojados (el 54,7 %). Se observó que se levantaban y acostaban más tarde y dormían 30 minutos más. Además, el uso de pantallas por esparcimiento aumentó 3 horas durante los días hábiles. El tiempo dedicado a la actividad física no varió, pero sí cambió el tipo de actividades: la natación y los deportes de equipo fueron reemplazados por ciclismo, caminatas y esquí. Conclusiones. El aislamiento por COVID-19 impactó sobre la salud emocional y los hábitos de los jóvenes. El aburrimiento, la irritabilidad y el desgano estuvieron más presentes durante el aislamiento. La posibilidad de realizar actividades al aire libre permitió que continuaran practicando deportes.

Dengue in Rio Grande do Sul, Brazil: 2014 to 2016

The first autochthonous dengue case in Rio Grande do Sul (RS), Southern Brazil, occurred in 2007. In 2008 and 2009, only imported cases were reported in RS, but from 2010 to 2013, reports of autochthonous infections increased significantly. This study analyzes and discusses laboratory, demographic, and clinical data regarding dengue cases in RS, from 2014 to 2016. This study analyzed 13,420 serum samples from notified patients with suspicion of dengue fever in RS from 2014 to 2016. Seasonality of positive cases, viral serotypes, and clinical and epidemiological aspects were analyzed. There was no difference in gender (P = .4); dengue fever occurred mainly in adults, with similar distribution among age groups. The number of dengue virus (DENV) cases increased from 89 cases in 2014 to 2518 in 2016. Dengue virus 1 was the most prevalent circulating serotype during this period (97.5% of cases). Dengue virus infections show peaks in March and April (late summer and early autumn), after periods of high temperatures and rainfall. In 2014, dengue cases were concentrated in the northwestern and eastern regions of RS, and in 2015 and 2016, the northern region also confirmed a high number of cases. With increase in DENV circulation in RS, a rise in the number of autochthonous infections was also observed, mainly in highly urbanized areas. This study revealed that circulation of DENV in RS increased significantly in 2015 and 2016, with a rise in the number of autochthonous infections and cocirculation with Chikungunya and Zika viruses, recently introduced into RS. (AU)

Dengue in Rio Grande do Sul, Brazil: 2014 to 2016.

The first autochthonous dengue case in Rio Grande do Sul (RS), Southern Brazil, occurred in 2007. In 2008 and 2009, only imported cases were reported in RS, but from 2010 to 2013, reports of autochthonous infections increased significantly. This study analyzes and discusses laboratory, demographic, and clinical data regarding dengue cases in RS, from 2014 to 2016. This study analyzed 13,420 serum samples from notified patients with suspicion of dengue fever in RS from 2014 to 2016. Seasonality of positive cases, viral serotypes, and clinical and epidemiological aspects were analyzed. There was no difference in gender (P = .4); dengue fever occurred mainly in adults, with similar distribution among age groups. The number of dengue virus (DENV) cases increased from 89 cases in 2014 to 2518 in 2016. Dengue virus 1 was the most prevalent circulating serotype during this period (97.5% of cases). Dengue virus infections show peaks in March and April (late summer and early autumn), after periods of high temperatures and rainfall. In 2014, dengue cases were concentrated in the northwestern and eastern regions of RS, and in 2015 and 2016, the northern region also confirmed a high number of cases. With increase in DENV circulation in RS, a rise in the number of autochthonous infections was also observed, mainly in highly urbanized areas. This study revealed that circulation of DENV in RS increased significantly in 2015 and 2016, with a rise in the number of autochthonous infections and cocirculation with Chikungunya and Zika viruses, recently introduced into RS.

Emerging arboviruses in Rio Grande do Sul, Brazil: Chikungunya and Zika outbreaks, 2014-2016.

QUESTIONS INVESTIGATED: The recent emergence of arboviruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil has posed a threat to human health and to the country's economy. Outbreaks occur mainly in tropical areas; however, increasing number of cases have been observed in Rio Grande do Sul (RS), the Southernmost state; therefore, surveillance of these arboviruses is essential for public health measures. DESIGN: In this study, we analyzed 1276 samples from patients with clinically suspected arboviral diseases between 2014 and 2016. Demographic and clinical data were collected and described; cases of microcephaly associated with congenital infection were analyzed. ESSENTIAL FINDINGS: Results show that CHIKV and ZIKV entered RS in 2014 and 2015, respectively, with imported cases confirmed. Autochthonous infections occurred in 2016 for both viruses, with a total of 5 autochthonous cases for CHIKV and 44 for ZIKV. Most patients were older than 21 years; the main symptoms were fever, arthralgia, myalgia, and headache; rash, conjunctivitis, and pruritus were also reported in ZIKV cases. Three cases of congenital Zika syndrome were confirmed in our study, while another 20 cases of microcephaly associated with congenital infection were confirmed (10 positive for syphilis, 6 for toxoplasmosis and 4 for cytomegalovirus). MAIN CONCLUSIONS: Considering co-circulation of different arbovirus in RS, including Dengue virus, CHIKV, and ZIKV, and the presence of Aedes aegypti and Aedes albopictus in the area, surveillance of patients infected by these viruses contributes to the control and prevention of such diseases. Practical difficulties in diagnosing these infections are discussed.

Emerging arboviruses in Rio Grande do Sul, Brazil: chikungunya and zika outbreaks, 2014­2016

Questions investigated: The recent emergence of arboviruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil has posed a threat to human health and to the country's economy. Outbreaks occur mainly in tropical areas; however, increasing number of cases have been observed in Rio Grande do Sul (RS), the Southernmost state; therefore, surveillance of these arboviruses is essential for public health measures. Design: In this study, we analyzed 1276 samples from patients with clinically suspected arboviral diseases between 2014 and 2016. Demographic and clinical data were collected and described; cases of microcephaly associated with congenital infection were analyzed. Essential findings: Results show that CHIKV and ZIKV entered RS in 2014 and 2015, respectively, with imported cases confirmed. Autochthonous infections occurred in 2016 for both viruses, with a total of 5 autochthonous cases for CHIKV and 44 for ZIKV. Most patients were older than 21 years; the main symptoms were fever, arthralgia, myalgia, and headache; rash, conjunctivitis, and pruritus were also reported in ZIKV cases. Three cases of congenital Zika syndrome were confirmed in our study, while another 20 cases of microcephaly associated with congenital infection were confirmed (10 positive for syphilis, 6 for toxoplasmosis and 4 for cytomegalovirus). Main conclusions: Considering co­circulation of different arbovirus in RS, including Dengue virus, CHIKV, and ZIKV, and the presence of Aedes aegypti and Aedes albopictus in the area, surveillance of patients infected by these viruses contributes to the control and prevention of such diseases. Practical difficulties in diagnosing these infections are discussed. (AU)

Percepción parental de la salud psicofísica, estado nutricional y salud bucal, en relación con características sociodemográficas en niños de Bariloche, Argentina: estudio epidemiológico / Parental perception of psychophysical health, nutritional status and oral health in relation to sociodemographic characteristics in children in Bariloche, Argentina: an epidemiological study

Introducción. Existen evidencias de la asociación de determinantes sociales con la salud infantil. Objetivo. Identificar características sociodemográficas asociadas a desigualdades en la salud infantil y evaluar el efecto acumulado sobre la salud de factores de riesgo basados en estas características. Población y métodos. Evaluamos niños de 4-13 años, de Bariloche, entre junio de 2008 y mayo de 2009. Características sociodemográficas consideradas: nivel socioeconómico, educación materna, embarazo adolescente, cobertura médica, inseguridad y hábitos familiares. Valoramos la percepción parental de la salud física y socioemocional, el estado nutricional y la salud bucal en relación con dichas características y con la acumulación de factores de riesgo. Utilizamos encuesta, antropometría y examen bucal. Resultados. Participaron 180 escolares. El nivel educativo materno se asoció con la salud física, socioemocional y bucal del niño. El porcentaje de niños con piezas faltantes o caries fue 77% entre aquellos cuyas madres, como máximo, habían completado el primario, comparado con 13% entre aquellos cuyas madres habían completado estudios terciarios/universitarios. La posibilidad de percepción de salud física y socioemocional no óptima aumentó con cada factor de riesgo 1,8 y 1,4 veces, respectivamente, y la posibilidad de caries o piezas faltantes se duplicó con cada factor de riesgo adicional. El 27,3% de los escolares presentó sobrepeso y el 8,7%, obesidad, y no se encontró asociación con características sociodemográficas. Conclusiones. El bajo nivel socioeconómico familiar y educativo materno se asoció con una mayor prevalencia de resultados de salud desfavorables. Múltiples factores de riesgo tienen un efecto acumulado sobre la percepción parental de la salud física y socioemocional y la salud bucal.

Introduction. There is evidence of an association between social determinants and child health. Objective. To identify sociodemographic characteristics related to child health inequalities and to analize the cumulative effect on health of risk factors based on these characteristics. Population and Methods. We evaluated 4-13 year-old children in Bariloche between June 2008 and May 2009. The following sociodemographic characteristics were taken into account: socioeconomic level, maternal education, adolescent pregnancy, medical coverage, unsafeness, and family habits. We assessed parental perception of physical, and social and emotional health, nutritional status and oral health in relation to these characteristics and the accumulation of risk factors. We used survey, anthropometry and oral examination. Results. One hundred and eighty students participated. The level of maternal education was associated with the child's physical, social and emotional, and oral health. The percentage of children with missing teeth or cavities reached 77% among those whose mothers had, at most, completed primary school, compared to 13% among those whose mothers had completed tertiary school or university. The possibility of perceiving a non-optimal physical, and social and emotional health increased 1.8 and 1.4 times with each risk factor, respectively, and the possibility of having missing teeth or cavities was twice as much with each additional risk factor. Overweight and obesity was observed in 27.3% and 8.7% of students, respectively, and no relationship was found with sociodemographic characteristics. Conclusions. A low family socioeconomic level and a low maternal education level were associated with a higher prevalence of unfavorable health outcomes. Multiple risk factors have an cumulative effect on parental perception of physical, social and emotional, and oral health.

Percepción parental de la salud psicofísica, estado nutricional y salud bucal, en relación con características sociodemográficas en niños de Bariloche, Argentina: estudio epidemiológico / Parental perception of psychophysical health, nutritional status and oral health in relation to sociodemographic characteristics in children in Bariloche, Argentina: an epidemiological study

Introducción. Existen evidencias de la asociación de determinantes sociales con la salud infantil. Objetivo. Identificar características sociodemográficas asociadas a desigualdades en la salud infantil y evaluar el efecto acumulado sobre la salud de factores de riesgo basados en estas características. Población y métodos. Evaluamos niños de 4-13 años, de Bariloche, entre junio de 2008 y mayo de 2009. Características sociodemográficas consideradas: nivel socioeconómico, educación materna, embarazo adolescente, cobertura médica, inseguridad y hábitos familiares. Valoramos la percepción parental de la salud física y socioemocional, el estado nutricional y la salud bucal en relación con dichas características y con la acumulación de factores de riesgo. Utilizamos encuesta, antropometría y examen bucal. Resultados. Participaron 180 escolares. El nivel educativo materno se asoció con la salud física, socioemocional y bucal del niño. El porcentaje de niños con piezas faltantes o caries fue 77% entre aquellos cuyas madres, como máximo, habían completado el primario, comparado con 13% entre aquellos cuyas madres habían completado estudios terciarios/universitarios. La posibilidad de percepción de salud física y socioemocional no óptima aumentó con cada factor de riesgo 1,8 y 1,4 veces, respectivamente, y la posibilidad de caries o piezas faltantes se duplicó con cada factor de riesgo adicional. El 27,3% de los escolares presentó sobrepeso y el 8,7%, obesidad, y no se encontró asociación con características sociodemográficas. Conclusiones. El bajo nivel socioeconómico familiar y educativo materno se asoció con una mayor prevalencia de resultados de salud desfavorables. Múltiples factores de riesgo tienen un efecto acumulado sobre la percepción parental de la salud física y socioemocional y la salud bucal.(AU)

Introduction. There is evidence of an association between social determinants and child health. Objective. To identify sociodemographic characteristics related to child health inequalities and to analize the cumulative effect on health of risk factors based on these characteristics. Population and Methods. We evaluated 4-13 year-old children in Bariloche between June 2008 and May 2009. The following sociodemographic characteristics were taken into account: socioeconomic level, maternal education, adolescent pregnancy, medical coverage, unsafeness, and family habits. We assessed parental perception of physical, and social and emotional health, nutritional status and oral health in relation to these characteristics and the accumulation of risk factors. We used survey, anthropometry and oral examination. Results. One hundred and eighty students participated. The level of maternal education was associated with the childs physical, social and emotional, and oral health. The percentage of children with missing teeth or cavities reached 77% among those whose mothers had, at most, completed primary school, compared to 13% among those whose mothers had completed tertiary school or university. The possibility of perceiving a non-optimal physical, and social and emotional health increased 1.8 and 1.4 times with each risk factor, respectively, and the possibility of having missing teeth or cavities was twice as much with each additional risk factor. Overweight and obesity was observed in 27.3% and 8.7% of students, respectively, and no relationship was found with sociodemographic characteristics. Conclusions. A low family socioeconomic level and a low maternal education level were associated with a higher prevalence of unfavorable health outcomes. Multiple risk factors have an cumulative effect on parental perception of physical, social and emotional, and oral health.(AU)

Parental perception of psychophysical health, nutritional status and oral health in relation to sociodemographic characteristics in children in Bariloche, Argentina: an epidemiological study.

INTRODUCTION: There is evidence of an association between social determinants and child health. OBJECTIVE: To identify sociodemographic characteristics related to child health inequalities and to analize the cumulative effect on health of risk factors based on these characteristics. POPULATION AND METHODS: We evaluated 4-13 year-old children in Bariloche between June 2008 and May 2009. The following sociodemographic characteristics were taken into account: socioeconomic level, maternal education, adolescent pregnancy, medical coverage, unsafeness, and family habits. We assessed parental perception of physical, and social and emotional health, nutritional status and oral health in relation to these characteristics and the accumulation of risk factors. We used survey, anthropometry and oral examination. RESULTS: One hundred and eighty students participated. The level of maternal education was associated with the child's physical, social and emotional, and oral health. The percentage of children with missing teeth or cavities reached 77% among those whose mothers had, at most, completed primary school, compared to 13% among those whose mothers had completed tertiary school or university. The possibility of perceiving a non-optimal physical, and social and emotional health increased 1.8 and 1.4 times with each risk factor, respectively, and the possibility of having missing teeth or cavities was twice as much with each additional risk factor. Overweight and obesity was observed in 27.3% and 8.7% of students, respectively, and no relationship was found with sociodemographic characteristics. CONCLUSIONS: A low family socioeconomic level and a low maternal education level were associated with a higher prevalence of unfavorable health outcomes. Multiple risk factors have an cumulative effect on parental perception of physical, social and emotional, and oral health.

Child psychomotor development and its relationship with socio-demographic and family stimulation factors in children from Bariloche, Argentina.

INTRODUCTION: This study analyzed the association between psychomotor development and socio-demographic and family stimulation factors in 3-year-old children from San Carlos de Bariloche. POPULATION AND METHODS: A total of 152 apparently healthy children aged 35-37 months old who attended municipal and private kindergartens were evaluated. Children's performance in personal-social, fne motor, language and gross motor skills development using the National Screening Test was analyzed. The relationship between environmental factors and the achievement of developmental milestones was studied using a multivariate logistic regression model. RESULTS: Twenty seven percent of children did not pass the test. The most common outcome measures associated with altered developmental milestones were no reading, low birth weight, and the parents' lower education level. The association with reading was always positive; and this also occurred in relation to the parents' education level. A low birth weight had a negative association with the possibility of passing four milestones, three of which were gross motor skills. Children who attended municipal kindergartens had a low performance in three language milestones, one personal-social milestone and one fne motor milestone when compared to national profles. CONCLUSIONS: The percentage of children who did not pass the test was 27%. The most common outcome measures associated with altered developmental milestones were lack of reading to the child, low birth weight, and the parents' lower education level.

Child psychomotor development and its relationship with socio-demographic and family stimulation factors in children from Bariloche, Argentina / Desarrollo psicomotor infantil y su relación con las características sociodemográfcas y de estimulación familiar en niños de la ciudad de Bariloche, Argentina

Introduction. This study analyzed the association between psychomotor development and socio-demographic and family stimulation factors in 3-year-old children from San Carlos de Bariloche. Population and Methods. A total of 152 apparently healthy children aged 35-37 months old who attended municipal and private kindergartens were evaluated. Children's performance in personal-social, fne motor, language and gross motor skills development using the National Screening Test was analyzed. The relationship between environmental factors and the achievement of developmental milestones was studied using a multivariate logistic regression model. Results. Twenty seven percent of children did not pass the test. The most common outcome measures associated with altered developmental milestones were no reading, low birth weight, and the parents' lower education level. The association with reading was always positive; and this also occurred in relation to the parents' education level. A low birth weight had a negative association with the possibility of passing four milestones, three of which were gross motor skills. Children who attended municipal kindergartens had a low performance in three language milestones, one personal-social milestone and one fne motor milestone when compared to national profles. Conclusions. The percentage of children who did not pass the test was 27%. The most common outcome measures associated with altered developmental milestones were lack of reading to the child, low birth weight, and the parents' lower education level.

Introducción. En este estudio se analizó la asociación entre el desarrollo psicomotor y factores sociodemográfcos y de estimulación familiar, en niños de 3 años de San Carlos de Bariloche. Población y métodos. Se evaluaron 152 niños aparentemente sanos, de 35 a 37 meses, concurrentes a jardines infantiles municipales y privados. Se analizó el desempeño de los niños en pautas de desarrollo personal-social, motor fno, lenguaje y motor grueso con la Prueba Nacional de Pesquisa. Se estudió la relación de factores medioambientales con el logro de pautas de desarrollo por medio del modelo de regresión logística multivariado. Resultados. El 27% de los niños no pasaron la prueba. Las variables asociadas con mayor frecuencia con pautas de desarrollo alteradas fueron la falta de lectura, bajo peso al nacer y el menor nivel de educación parental. La asociación con la lectura siempre fue positiva; lo mismo ocurrió en relación con el nivel educativo paternal. El bajo peso al nacer se asoció negativamente con la posibilidad de pasar cuatro pautas, tres de tipo motor grueso. Los niños de establecimientos municipales mostraron bajo rendimiento en tres pautas de lenguaje, una personal-social y una de tipo motor fno en comparación con los perfles nacionales.

Child psychomotor development and its relationship with socio-demographic and family stimulation factors in children from Bariloche, Argentina / Desarrollo psicomotor infantil y su relación con las características sociodemográfcas y de estimulación familiar en niños de la ciudad de Bariloche, Argentina

Introduction. This study analyzed the association between psychomotor development and socio-demographic and family stimulation factors in 3-year-old children from San Carlos de Bariloche. Population and Methods. A total of 152 apparently healthy children aged 35-37 months old who attended municipal and private kindergartens were evaluated. Childrens performance in personal-social, fne motor, language and gross motor skills development using the National Screening Test was analyzed. The relationship between environmental factors and the achievement of developmental milestones was studied using a multivariate logistic regression model. Results. Twenty seven percent of children did not pass the test. The most common outcome measures associated with altered developmental milestones were no reading, low birth weight, and the parents lower education level. The association with reading was always positive; and this also occurred in relation to the parents education level. A low birth weight had a negative association with the possibility of passing four milestones, three of which were gross motor skills. Children who attended municipal kindergartens had a low performance in three language milestones, one personal-social milestone and one fne motor milestone when compared to national profles. Conclusions. The percentage of children who did not pass the test was 27%. The most common outcome measures associated with altered developmental milestones were lack of reading to the child, low birth weight, and the parents lower education level.(AU)

Introducción. En este estudio se analizó la asociación entre el desarrollo psicomotor y factores sociodemográfcos y de estimulación familiar, en niños de 3 años de San Carlos de Bariloche. Población y métodos. Se evaluaron 152 niños aparentemente sanos, de 35 a 37 meses, concurrentes a jardines infantiles municipales y privados. Se analizó el desempeño de los niños en pautas de desarrollo personal-social, motor fno, lenguaje y motor grueso con la Prueba Nacional de Pesquisa. Se estudió la relación de factores medioambientales con el logro de pautas de desarrollo por medio del modelo de regresión logística multivariado. Resultados. El 27% de los niños no pasaron la prueba. Las variables asociadas con mayor frecuencia con pautas de desarrollo alteradas fueron la falta de lectura, bajo peso al nacer y el menor nivel de educación parental. La asociación con la lectura siempre fue positiva; lo mismo ocurrió en relación con el nivel educativo paternal. El bajo peso al nacer se asoció negativamente con la posibilidad de pasar cuatro pautas, tres de tipo motor grueso. Los niños de establecimientos municipales mostraron bajo rendimiento en tres pautas de lenguaje, una personal-social y una de tipo motor fno en comparación con los perfles nacionales.(AU)

Child psychomotor development and its relationship with socio-demographic and family stimulation factors in children from Bariloche, Argentina. / Child psychomotor development and its relationship with socio-demographic and family stimulation factors in children from Bariloche, Argentina.

INTRODUCTION: This study analyzed the association between psychomotor development and socio-demographic and family stimulation factors in 3-year-old children from San Carlos de Bariloche. POPULATION AND METHODS: A total of 152 apparently healthy children aged 35-37 months old who attended municipal and private kindergartens were evaluated. Childrens performance in personal-social, fne motor, language and gross motor skills development using the National Screening Test was analyzed. The relationship between environmental factors and the achievement of developmental milestones was studied using a multivariate logistic regression model. RESULTS: Twenty seven percent of children did not pass the test. The most common outcome measures associated with altered developmental milestones were no reading, low birth weight, and the parents lower education level. The association with reading was always positive; and this also occurred in relation to the parents education level. A low birth weight had a negative association with the possibility of passing four milestones, three of which were gross motor skills. Children who attended municipal kindergartens had a low performance in three language milestones, one personal-social milestone and one fne motor milestone when compared to national profles. CONCLUSIONS: The percentage of children who did not pass the test was 27

. The most common outcome measures associated with altered developmental milestones were lack of reading to the child, low birth weight, and the parents lower education level.